2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-126146
    PKC-iota inhibitor 1 2328094-11-5 99.76%
    PKC-iota inhibitor 1 is a protein kinase C-iota (PKC-ι) inhibitor with an IC50 value of 0.34 μM. PKC-iota inhibitor 1 can be used for the study of cancer.
    PKC-iota inhibitor 1
  • HY-128738
    Thymidine-5'-monophosphate (disodium) salt 33430-62-5 99.79%
    Thymidine-5'-monophosphate disodium salt is an endogenous metabolite.
    Thymidine-5'-monophosphate (disodium) salt
  • HY-131648
    1-Oleoyl-2-acetyl-sn-glycerol 86390-77-4 ≥99.0%
    1-Oleoyl-2-acetyl-sn glycerol is a synthetic, cell permeable diacylglycerol analog. 1-Oleoyl-2-acetyl-sn glycerol activates calcium-dependent protein kinase C (PKC) and induces the superoxide-production.
    1-Oleoyl-2-acetyl-sn-glycerol
  • HY-136561
    GRK5-IN-2 1642839-27-7 99.92%
    GRK5-IN-2 (compound 707), a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor. GRK5-IN-2 regulates the expression and/or release of insulin and is useful for the metabolic disease research.
    GRK5-IN-2
  • HY-141619
    Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:5) 8064-90-2 ≥99.0%
    Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:5) is an active compound for toxoplasmic encephalitis inhibition, as well as inhibition in protozoan and bacterial infections.
    Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:5)
  • HY-141894
    5-Ph-IAA-AM 2990123-10-7 99.04%
    5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA (HY-134653) analog which contains an acetoxymethyl (AM) group. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation.
    5-Ph-IAA-AM
  • HY-A0181A
    Adenosine 5'-monophosphate monohydrate 18422-05-4 ≥98.0%
    Adenosine 5'-monophosphate monohydrate is an adenosine A1 receptor agonist. Adenosine 5'-monophosphate monohydrate has significant antiviral activity against HSV-1 and HSV-2.
    Adenosine 5'-monophosphate monohydrate
  • HY-B0371F
    Terazosin hydrochloride 63074-08-8 99.72%
    Terazosin hydrochloride is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment.
    Terazosin hydrochloride
  • HY-B1039A
    Ambroxol hydrochloride 23828-92-4 99.92%
    Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.
    Ambroxol hydrochloride
  • HY-W005629
    Leelamine 1446-61-3 ≥98.0%
    Leelamine is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor with an IC50 value of 9.5 μM, showing a blood glucose lowering effect in the diabetic mouse. Leelamine is also a weak agonist of cannabinoid receptors CB1 and CB2. Leelamine decreases mitotic activity, prostate-specific antigen expression and induces Apoptosis to cell death in cancer cells.
    Leelamine
  • HY-W008638
    2'-Deoxyinosine 890-38-0 ≥98.0%
    2’-deoxyadenosine inhibits the growth of human colon-carcinoma cell lines and is found to be associated with purine nucleoside phosphorylase (PNP) deficiency.
    2'-Deoxyinosine
  • HY-W009731
    Dibenzoylmethane 120-46-7 ≥98.0%
    Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2.
    Dibenzoylmethane
  • HY-W015967
    Glycolic acid 79-14-1
    Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
    Glycolic acid
  • HY-W015913S
    Sodium 2-oxopropanoate-13C3 142014-11-7 ≥98.0%
    Sodium 2-oxopropanoate-13C3 is the 13C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[1][2].
    Sodium 2-oxopropanoate-13C3
  • HY-W018035
    DL-Glyceric Acid (20% in water) 473-81-4
    DL-Glyceric Acid (20% in water) is a metabolite of plants and mammals and exists in two configurations, D and L.
    DL-Glyceric Acid (20% in water)
  • HY-17566
    Capreomycin sulfate 1405-37-4 ≥99.0%
    Capreomycin sulfate is a macrocyclic peptide antibiotic that inhibits phenylalanine synthesis in mycobacterial ribosomal translation. Capreomycin sulfate has anti-amyloidogenic and pro-fibrinolytic activities, reducing amyloid-induced cytotoxicity by inhibiting the occurrence of amyloid fibrillation. Capreomycin sulfate can be used in the study of multidrug-resistant tuberculosis, type 2 diabetes, Alzheimer's disease and Parkinson's disease.
    Capreomycin sulfate
  • HY-136064
    4,4'-Dimethoxychalcone 2373-89-9 99.57%
    4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties.
    4,4'-Dimethoxychalcone
  • HY-B2209A
    Hydroxocobalamin monohydrochloride 59461-30-2 ≥98.0%
    Hydroxocobalamin monohydrochloride (Vitamin B12a monohydrochloride) is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia.
    Hydroxocobalamin monohydrochloride
  • HY-B0373
    Tiopronin 1953-02-2 ≥98.0%
    Tiopronin is a diffusible antioxidant, an antidote to heavy metal poisoning and a radioprotective agent. Tiopronin can control the rate of cystine precipitation and excretion and has the potential for cystinuria, rheumatoid arthritis and hepatic disorders.
    Tiopronin
  • HY-N0179
    Ecdysone 3604-87-3
    Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979).
    Ecdysone
Cat. No. Product Name / Synonyms Application Reactivity